"Proofing job for Particle Works abstract"

Proofing job for Particle Works abstract

White Paper: Particle Works

The development of nanoparticles (NPs) as drug carriers for specific action sites has gained significant attention in recent times. However, the synthesis of NPs for drug delivery is complex and challenging, and therefore requires consistent, low-cost, and efficient materials. Particle Works offers NP synthesis solutions that are underpinned by microfluidics and automation, enabling researchers to accelerate their nanomedicine development.

The Automated Nanoparticle (ANP) System provides both automated process optimization and continuous manufacturing capabilities on a single platform. This system allows scientists to automatically optimize process parameters and generate test samples. Particle Works offers the ALiS System for screening low volumes of various formulations in a 96-well plate format, while the ANP System is used to optimize the size, shape and structure of NPs ahead of final production and commercialization. The ANP System can be used initially in ’protocol mode’, where the system can sequentially execute a table of automated and low volume experiments from a fixed pair of injected reagents. Using the Flow Control Centre (FCC) software, users can optimize the flow rate ratio (FRR), total flow rate (TFR), NP precursor volume, sample collection volume, and select optional in-line dilution. Once a desired set of experimental conditions has been identified, the user can then switch to ‘continuous mode’ to create liters of NPs for pre-clinical trials and extensive characterization. Unique in this dual capability, the ANP System bridges the gap between formulation screening and commercial scale manufacturing in a single system solution.